Initial Broth Microdilution Quality Control Guidelines for Debio 1452, a FabI Inhibitor Antimicrobial Agent
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چکیده
منابع مشابه
Initial broth microdilution quality control guidelines for Debio 1452, a FabI inhibitor antimicrobial agent.
Debio 1452, formerly called AFN-1252 (Fig. 1), is an investigational FabI inhibitor that has demonstrated potent activity against Staphylococcus aureus (1–5). Currently, Debio 1450 (prodrug of Debio 1452) is in clinical development by the Debiopharm Group (6, 7). Debio 1452 selectively inhibits bacterial enoyl-acyl carrier protein (enoyl-ACP) reductase, an essential step in the elongation cycle...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2015
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01690-15